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张卫 Wei Zhang

教授

专业:分析化学

简介:
山东禹城人,博士,教授,硕士生导师。山东省杰出青年基金获得者。

个人介绍

      张卫,山东禹城人,博士,教授,硕士生导师。山东省杰出青年基金获得者。2012年毕业于南开大学化学学院分析化学专业获博士学位,同年进入山东师范大学化学化工与材料科学学院工作至今。主要从事仿生荧光传感材料的设计、制备及应用研究。针对复杂样品中目标蛋白质的定量分析问题,开展了一系列高灵敏的荧光检测方法研究,围绕细胞内重要的活性功能分子,发展了系列的荧光成像分析方法,取得了多项创新性和系统性的科研成果。(1)利用分子印迹技术提高了荧光材料对目标蛋白质分子的选择性,发展了蛋白质特异性识别的荧光检测方法,为蛋白组学提供新的研究策略和分析方法。(2)构建了高灵敏、高选择性的荧光分析体系,并用于细胞及活体内活性小分子成像分析。在学术期刊发表论文32篇,SCI他引1329次,其中以第一或通讯作者发表在Angew. Chem. Int. Ed. 2篇, Chem. Sci. 2篇,Chem. Commun. 2篇,Anal. Chem. 2篇,其中单篇他引次数过百的论文3篇。研究结果曾被多家杂志如Chem. Soc. Rev., Angew. Chem. Int. Ed.等正面报道和评述。

 

主要论文:

1Wei Zhang, Jun Lu, Xiaonan Gao, Ping Li*, Wen Zhang, Yu Ma, Hui Wang, Bo Tang*. Enhanced Photodynamic Therapy by Reduced Levels of Intracellular Glutathione Obtained By Employing a Nano-MOF with CuII as Active Center. Angew. Chem. Int. Ed., 2018, 57, 4891-4896.

2Wei Zhang, Wei Liu, Ping Li*, Haibin Xiao, Hui Wang, and Bo Tang*. A Fluorescence Nanosensor for Glycoproteins with Activity Based on the Molecularly Imprinted Spatial Structure of the Target and Boronate Affinity. Angew. Chem. Int. Ed., 2014, 53, 12489-12493.

3Wei Zhang*, Ruixia Wang, Wei Liu, Xin Wang, Ping Li*, Wen Zhang, Hui Wang and Bo Tang*. Te-containing carbon dots for fluorescence imaging of superoxide anion in mice during acute strenuous exercise or emotional changes. Chem. Sci., 2018, 9, 721-727.

4Wei Zhang*, Jiheng Xu, Ping Li, Xiaonan Gao, Wen Zhang, Hui Wang and Bo Tang*. Treatment of hyperphosphatemia based on specific interaction between phosphorus and active center Zr(IV) of nano-MOFs. Chem. Sci., 2018, 9, 7483-7487.

5Wei Zhang, Junqing Kang, Ping Li*, Lu Liu, Hui Wang and Bo Tang*. Two-photon fluorescence imaging of sialylated glycans in vivo based on a sialic acid imprinted conjugated polymer nanoprobe. Chem. Commun., 2016, 52, 13991-13994.

6Wei Zhang, Junqing Kang, Ping Li*, Hui Wang, and Bo Tang*. Dual Signaling Molecule Sensor for Rapid Detection of Hydrogen Sulfide Based on Modified Tetraphenylethylene. Anal. Chem., 2015, 87, 8964-8969.

7Wei Zhang, Wei Liu, Ping Li*, Fang Huang, Hui Wang, and Bo Tang*. Rapid-Response Fluorescent Probe for Hydrogen Peroxide in Living Cells Based on Increased Polarity of C-B Bonds. Anal. Chem., 2015, 87, 9825-9828.

8Wei Zhang, Wei Liu, Ping Li*, Junqing Kang, Jiaoyang Wang, Hui Wang and Bo Tang*. Reversible two-photon fluorescent probe for imaging of hypochlorous acid in live cells and in vivo. Chem. Commun., 2015, 51, 10150-10153.

9Wei Zhang, Xi-Wen He, Wen-You Li, Yu-Kui Zhang. Selective capture and fluorescent quantification of glycoproteins by using aminophenylboronic acid functionalized mesoporous silica coating CdTe quantum dots. J. Mater. Chem. B, 2013, 1: 347-352.

10Wei Zhang, Xi-Wen He, Yang Chen, Wen-You Li, Yu-Kui Zhang. Molecularly imprinted polymer anchored on the surface of denatured bovine serum albumin modified CdTe quantum dots as fluorescent artificial receptor for recognition of target protein. Biosens. Bioelectron. 2012, 31: 84-89.

11Wei Zhang, Xi-Wen He, Wen-You Li, Yu-Kui Zhang. Thermo-sensitive imprinted polymer coating CdTe quantum dots for target protein specific recognition. Chem. Commun., 2012, 48: 1757-1759.

12Wei Zhang, Xi-Wen He, Yang Chen, Wen-You Li, Yu-Kui Zhang. Composite of CdTe quantum dots and molecularly imprinted polymer as a sensing material for cytochrome c. Biosens. Bioelectron., 2011, 26: 2553-2558.

13Wei Zhang, Lei Qin, Xi-Wen He, Wen-You Li, Yu-Kui Zhang. Novel surface modified molecularly imprinted polymer using acryloyl-β-cyclodextrin and acrylamide as monomers for selective recognition of lysozyme in aqueous solution. J. Chromatogr. A, 2009, 1216: 4560-4567.

 

承担项目:

1.国家自然科学基金面上项目,21874084,细胞与活体中功能蛋白糖基化与磷酸化位点识别与互作实时原位荧光成像,2019/01-2022/12,66万,在研,主持。

2.山东省属高校优秀青年人才联合基金项目,ZR2015JL008,基于分子印迹技术的新型传感体系的构建及其在糖蛋白识别中的应用研究,2015/07-2016/1230万元,已结题,主持。

3.国家自然科学基金青年项目,21305080,用于非胁迫状态细胞中低浓度活性氧自由基检测的聚合物放大型荧光探针的设计与制备,2014/01-2016/1225万元,已结题,主持。

4. 山东省重点研发计划项目,2017GSF18196,基于抗原决定基印迹技术的新型荧光纳米探针的制备及应用研究,2017/03-2019/03, 10万元,在研,主持。

5.山东省自然科学基金青年项目,ZR2013BQ005,基于硼与糖蛋白特异性作用的分子印迹型荧光探针的制备及其应用研究,2013/10-2016/107万元,已结题,主持。